Division of Gastroenterology, The Affiliated Huaian No. 1 People's Hospital of Nanjing Medical University, Jiangsu, China. Ningbo Pace Translational Medical Research Center, Ningbo, China. Division of Gastroenterology, Yinzhou Hospital Affiliated to Medical School of Ningbo University, Ningbo, China. Division of Gastroenterology, Changzheng Hospital Affiliated to Second Military Medical University, Shanghai, China. Division of Gastroenterology and Hepatology, Johns Hopkins Medicine, Baltimore, Maryland. Division of Gastroenterology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.